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Lung on a chip : ウィキペディア英語版 | Lung on a chip Lung on a Chip is a complex, three-dimensional model of a living, breathing human lung on a microchip. The device is made using human lung and blood vessel cells and it can predict absorption of airborne nanoparticles and mimic the inflammatory response triggered by microbial pathogens. It can be used to test the effects of environmental toxins, absorption of aerosolized therapeutics, and the safety and efficacy of new drugs. It is expected to become an alternative to animal testing. The lung-on-a-chip places two layers of living tissues—the lining of the lung's air sacs and the blood vessels that surround them—across a porous, flexible boundary. Air is delivered to the lung lining cells, a rich culture medium flows in the capillary channel to mimic blood, and cyclic mechanical stretching is generated by a vacuum applied to the chambers adjacent to the cell culture channels to mimic breathing. The research findings for lung-on-a-chip were published in the June 25, 2010, issue of Science, the academic journal of the American Association for the Advancement of Science. The research was funded by the National Institutes of Health, the American Heart Association, and the Wyss Institute for Biologically Inspired Engineering at Harvard University. ==Inventors== The technology was developed by Donald E. Ingber, M.D., Ph.D., an American cell biologist who is the Founding Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University, and Dan Dongeun Huh, Ph.D., who was a Technology Development Fellow at the Wyss Institute and is now Wilf Family Term Chair Assistant Professor in Bioengineering at the University of Pennsylvania. The device was created using a microfabrication strategy known as soft lithography that was pioneered by George M. Whitesides, an American chemist, who is a professor of chemistry at Harvard, as well as a Wyss Institute core faculty member.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Lung on a chip」の詳細全文を読む
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